Prescribing InformationMedication GuideU.S. Healthcare Professionals

Taking MYQORZO™

MYQORZO is the CMI thoughtfully designed with you in mind

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Reach your individualized dose

Your healthcare provider may begin adjusting your dose as early as 2 weeks after starting MYQORZO, reaching your individualized maintenance dose within 8 weeks.*

Step One: Starting dose five milligrams plus echo two to eight weeks after starting treatment; Step Two: Dose increased in five milligram increments to your individualized maintenance dose plus echo two to eight weeks after any dose change; Step Three: Maintain individualized dose plus echo every six months. Depending on results of your echocardiogram, you may need to have follow-up every three months.

How should I take MYQORZO?

  • Take MYQORZO exactly as your healthcare provider tells you to take it
  • Do not change your dose of MYQORZO without talking to your healthcare provider first
  • Take MYQORZO 1 time a day, at about the same time each day
  • Take MYQORZO with or without meals
  • Swallow the MYQORZO tablet whole
  • If you miss a dose of MYQORZO, take it as soon as possible and take your next dose at your regularly scheduled time the next day. Do not take 2 doses on the same day to make up for a missed dose
  • Your healthcare provider may change your dose, or temporarily stop your treatment with MYQORZO if you have certain side effects
  • If you take too much MYQORZO, call your healthcare provider or the Poison Control Help Line at 1-800-222-1222, or go to the nearest hospital emergency room right away

Once your healthcare provider finds your individualized dose, it's important to take MYQORZO daily, as directed.

*Based on echocardiograms performed 2 to 8 weeks after starting treatment and after any dose change.

†MYQORZO may be increased at 5-mg increments up to 20 mg. If at any point you have a drop in your left ventricular ejection fraction (LVEF), experience a severe illness, or start taking certain medications, your cardiologist may need to lower your dose of MYQORZO or even temporarily stop it.

CMI=cardiac myosin inhibitor.

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See what resources may be available to help you get started on MYQORZO.

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Want to know about MYQORZO safety and side effects?

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IMPORTANT SAFETY INFORMATION

What is the most important information I should know about MYQORZO?

MYQORZO can cause serious side effects, including:

  • Heart failure, a condition where the heart cannot pump with enough force, is a serious condition that can lead to death. You must have echocardiograms (echos) before and during treatment with MYQORZO and monitor for signs and symptoms of heart failure. People who develop a serious illness such as a serious infection or who develop a new or worsening irregular heartbeat have a greater risk of heart failure during treatment with MYQORZO

    Tell your healthcare provider or get medical help right away if you develop new or worsening shortness of breath, chest pain, fatigue, leg swelling, a racing sensation in your heart (palpitations), or rapid weight gain.

  • The risk of heart failure is also increased when MYQORZO is taken with certain other medicines. Tell your healthcare provider about any prescribed and over-the-counter medicines you take, before and during your treatment with MYQORZO

  • Because of the risk of heart failure, MYQORZO is only available through a restricted distribution program called the MYQORZO Risk Evaluation and Mitigation Strategy (REMS) Program

    • Your healthcare provider must be enrolled in the MYQORZO REMS Program for you to be prescribed MYQORZO
    • Before you start treatment with MYQORZO, you must enroll in the MYQORZO REMS Program. Talk to your healthcare provider about how to enroll in the program. You will be given information about the program when you enroll
    • Before you take MYQORZO, your healthcare provider and pharmacist will make sure you understand how to take MYQORZO safely, which will include returning for echos when advised by your healthcare provider. MYQORZO can only be dispensed by a certified pharmacy that participates in the MYQORZO REMS Program
    • If you have any questions about the MYQORZO REMS Program, ask your healthcare provider, go to www.MYQORZOREMS.com, or call 1-844-285-7367

Who should not take MYQORZO?

Do not take MYQORZO if you take a medicine called rifampin.

What are the possible side effects of MYQORZO?

MYQORZO can cause serious side effects, including heart failure.

What should I tell my healthcare provider before taking MYQORZO?

Before taking MYQORZO, tell your healthcare provider about all of your medical conditions, including if you:

  • Are pregnant or plan to become pregnant. It is not known if MYQORZO can cause harm to your unborn baby. Tell your healthcare provider if you become pregnant during treatment or within 3 weeks after the last dose of MYQORZO. There is a pregnancy study for MYQORZO. Your healthcare provider should report your pregnancy exposure to Cytokinetics, Inc
  • Are breastfeeding or plan to breastfeed. It is not known if MYQORZO passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment with MYQORZO

Before and during MYQORZO treatment, tell your healthcare provider about all the prescription and over-the-counter medicines, vitamins, and herbal supplements you take. Taking MYQORZO with certain medicines may lead to increased levels of MYQORZO in your blood and increase the risk of heart failure. Do not stop or change the dose of a medicine or start a new medicine without telling your healthcare provider.

Especially tell your healthcare provider if you take fluconazole (if used for more than 3 days), voriconazole, or fluvoxamine.

What are the most common side effects of MYQORZO?

The most common side effect of MYQORZO is high blood pressure (hypertension).

These are not all the possible side effects of MYQORZO. Talk to your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects to Cytokinetics at 1-833-633-2986.

INDICATION AND USAGE

MYQORZO is a prescription medicine used to treat adults with symptomatic obstructive cardiomyopathy (oHCM) to improve functional capacity and symptoms.

It is not known if MYQORZO is safe and effective in children.

Please see full Prescribing Information, including Boxed WARNING, and Medication Guide.