Taking MYQORZO™

Side effects and safety

Actor portrayal.
People doing water aerobics

MYQORZO side effects

Heart failure icon

MYQORZO can cause serious side effects, including heart failure, which is why your doctor will monitor how your heart is functioning.

Tell your healthcare provider or get medical help right away if you develop new or worsening:

  • Shortness of breath
  • Swelling in your legs
  • Fatigue
  • Chest pain
  • Racing sensation in your heart (palpitations)
  • Rapid weight gain

>> No participants in the clinical trial had to interrupt treatment or experienced worsening heart failure due to a drop in ejection fraction ⓘ.

High blood pressure icon

The most common side effect of MYQORZO is high blood pressure (hypertension).

In the clinical trial, it was reported for 8% of participants taking MYQORZO and 2% on placebo.

Taking MYQORZO with other medicines

MYQORZO can be added to:

  • Medicines you may be taking for obstructive HCM, including beta blockers (such as metoprolol), calcium channel blockers (such as verapamil and diltiazem), and disopyramide
  • Medicines used for other conditions commonly seen in people with oHCM

In most cases, that may mean you can start MYQORZO with minimal need to adjust the dose or change other medicines you take. It’s important that you tell your healthcare team about any medicines you are taking.

Medicines you can't take with MYQORZO:

Prescription medicine icon

Prescription
Medicines

  • Rifampin

May require dose change with MYQORZO:

Prescription medicine icon

Prescription
Medicines

  • Fluconazole (if used for more than 3 days)
  • Voriconazole
  • Fluvoxamine

>> Always speak to your healthcare provider when starting and stopping medications, including over-the-counter products and supplements.

Safety considerations

Doctor icon

Before and during treatment with MYQORZO, tell your healthcare provider about:

  • All medicines you take, including over-the-counter medicines, vitamins, and herbal supplements. Taking MYQORZO with certain medicines may increase your risk of heart failure. Do not change the dose or stop taking a medicine or start a new medicine without telling your healthcare provider.

  • All of your medical conditions, including if you are:

    • Pregnant, plan to be, or become pregnant within 3 weeks of your last dose. It is not known if MYQORZO can harm your unborn baby
    • Breastfeeding or plan to breastfeed. It is not known if MYQORZO passes into your breastmilk
REMS information icon

REMS Program

Learn about this program developed to reinforce the safe use of MYQORZO.

Chat bubble icon

Is MYQORZO for you?

Read through some questions to consider and discuss with your healthcare provider.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about MYQORZO?

MYQORZO can cause serious side effects, including:

  • Heart failure, a condition where the heart cannot pump with enough force, is a serious condition that can lead to death. You must have echocardiograms (echos) before and during treatment with MYQORZO and monitor for signs and symptoms of heart failure. People who develop a serious illness such as a serious infection or who develop a new or worsening irregular heartbeat have a greater risk of heart failure during treatment with MYQORZO

    Tell your healthcare provider or get medical help right away if you develop new or worsening shortness of breath, chest pain, fatigue, leg swelling, a racing sensation in your heart (palpitations), or rapid weight gain.

  • The risk of heart failure is also increased when MYQORZO is taken with certain other medicines. Tell your healthcare provider about any prescribed and over-the-counter medicines you take, before and during your treatment with MYQORZO

  • Because of the risk of heart failure, MYQORZO is only available through a restricted distribution program called the MYQORZO Risk Evaluation and Mitigation Strategy (REMS) Program

    • Your healthcare provider must be enrolled in the MYQORZO REMS Program for you to be prescribed MYQORZO
    • Before you start treatment with MYQORZO, you must enroll in the MYQORZO REMS Program. Talk to your healthcare provider about how to enroll in the program. You will be given information about the program when you enroll
    • Before you take MYQORZO, your healthcare provider and pharmacist will make sure you understand how to take MYQORZO safely, which will include returning for echos when advised by your healthcare provider. MYQORZO can only be dispensed by a certified pharmacy that participates in the MYQORZO REMS Program
    • If you have any questions about the MYQORZO REMS Program, ask your healthcare provider, go to www.MYQORZOREMS.com, or call 1-844-285-7367

Who should not take MYQORZO?

Do not take MYQORZO if you take a medicine called rifampin.

What are the possible side effects of MYQORZO?

MYQORZO can cause serious side effects, including heart failure.

What should I tell my healthcare provider before taking MYQORZO?

Before taking MYQORZO, tell your healthcare provider about all of your medical conditions, including if you:

  • Are pregnant or plan to become pregnant. It is not known if MYQORZO can cause harm to your unborn baby. Tell your healthcare provider if you become pregnant during treatment or within 3 weeks after the last dose of MYQORZO. There is a pregnancy study for MYQORZO. Your healthcare provider should report your pregnancy exposure to Cytokinetics, Inc
  • Are breastfeeding or plan to breastfeed. It is not known if MYQORZO passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment with MYQORZO

Before and during MYQORZO treatment, tell your healthcare provider about all the prescription and over-the-counter medicines, vitamins, and herbal supplements you take. Taking MYQORZO with certain medicines may lead to increased levels of MYQORZO in your blood and increase the risk of heart failure. Do not stop or change the dose of a medicine or start a new medicine without telling your healthcare provider.

Especially tell your healthcare provider if you take fluconazole (if used for more than 3 days), voriconazole, or fluvoxamine.

What are the most common side effects of MYQORZO?

The most common side effect of MYQORZO is high blood pressure (hypertension).

These are not all the possible side effects of MYQORZO. Talk to your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects to Cytokinetics at 1-833-633-2986.

INDICATION AND USAGE

MYQORZO is a prescription medicine used to treat adults with symptomatic obstructive hypertrophic cardiomyopathy (oHCM) to improve functional capacity and symptoms.

It is not known if MYQORZO is safe and effective in children.

Please see full Prescribing Information, including Boxed WARNING, and Medication Guide.