Prescribing InformationMedication GuideU.S. Healthcare Professionals

Taking MYQORZO™

Before starting MYQORZO

Before starting MYQORZO, you’ll want to partner with your healthcare team to complete some important steps. Be sure to ask any questions you have so you can get started on the right foot.

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Here are some things to expect before starting treatment:

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Your healthcare provider will talk with you about your medical status, including if you:

  • Are pregnant or plan to become pregnant, as it is not known if MYQORZO can cause harm to your unborn baby
  • Are breastfeeding or planning to breastfeed, as it is not known if MYQORZO passes into breast milk
  • Are taking any medicines, including prescription and over-the-counter medicines, vitamins, and herbal supplements
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Your healthcare provider will order an echocardiogram if you haven't had one recently. Echocardiograms are how your provider will confirm your eligibility for treatment with MYQORZO and monitor the safety and effectiveness of your treatment

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Your healthcare provider will discuss the Risk Evaluation and Mitigation Strategy (REMS) program with you and:

  • Discuss the risks and benefits of MYQORZO treatment
  • Provide you with the REMS Patient Brochure and MYQORZO Medication Guide
  • Enroll you in the REMS program or refer you to a REMS-certified healthcare professional who can enroll you
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Your healthcare team can walk you through the full treatment process

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Learn about patient support services for MYQORZO

MYQORZO may be safe to take with your other medicines

MYQORZO can be added to certain other obstructive hypertrophic cardiomyopathy (oHCM) medicines that you might be taking, including beta blockers (such as metoprolol), calcium channel blockers (such as verapamil and diltiazem), and disopyramide.

MYQORZO can also be taken with many medications used for other conditions commonly seen in people with obstructive HCM. For most people, this may mean you can start MYQORZO with minimal need to change your other medications or adjust doses. It’s important that you talk to your healthcare team about any medicines you are taking.

Medicines you can't take with MYQORZO:

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Prescription
Medicines

  • Rifampin

May require dose change with MYQORZO:

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Prescription
Medicines

  • Fluconazole (if used for more than 3 days)
  • Voriconazole
  • Fluvoxamine

Always speak to your healthcare provider when starting and stopping medications, including over-the-counter products and supplements.

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IMPORTANT SAFETY INFORMATION

What is the most important information I should know about MYQORZO?

MYQORZO can cause serious side effects, including:

  • Heart failure, a condition where the heart cannot pump with enough force, is a serious condition that can lead to death. You must have echocardiograms (echos) before and during treatment with MYQORZO and monitor for signs and symptoms of heart failure. People who develop a serious illness such as a serious infection or who develop a new or worsening irregular heartbeat have a greater risk of heart failure during treatment with MYQORZO

    Tell your healthcare provider or get medical help right away if you develop new or worsening shortness of breath, chest pain, fatigue, leg swelling, a racing sensation in your heart (palpitations), or rapid weight gain.

  • The risk of heart failure is also increased when MYQORZO is taken with certain other medicines. Tell your healthcare provider about any prescribed and over-the-counter medicines you take, before and during your treatment with MYQORZO

  • Because of the risk of heart failure, MYQORZO is only available through a restricted distribution program called the MYQORZO Risk Evaluation and Mitigation Strategy (REMS) Program

    • Your healthcare provider must be enrolled in the MYQORZO REMS Program for you to be prescribed MYQORZO
    • Before you start treatment with MYQORZO, you must enroll in the MYQORZO REMS Program. Talk to your healthcare provider about how to enroll in the program. You will be given information about the program when you enroll
    • Before you take MYQORZO, your healthcare provider and pharmacist will make sure you understand how to take MYQORZO safely, which will include returning for echos when advised by your healthcare provider. MYQORZO can only be dispensed by a certified pharmacy that participates in the MYQORZO REMS Program
    • If you have any questions about the MYQORZO REMS Program, ask your healthcare provider, go to www.MYQORZOREMS.com, or call 1-844-285-7367

Who should not take MYQORZO?

Do not take MYQORZO if you take a medicine called rifampin.

What are the possible side effects of MYQORZO?

MYQORZO can cause serious side effects, including heart failure.

What should I tell my healthcare provider before taking MYQORZO?

Before taking MYQORZO, tell your healthcare provider about all of your medical conditions, including if you:

  • Are pregnant or plan to become pregnant. It is not known if MYQORZO can cause harm to your unborn baby. Tell your healthcare provider if you become pregnant during treatment or within 3 weeks after the last dose of MYQORZO. There is a pregnancy study for MYQORZO. Your healthcare provider should report your pregnancy exposure to Cytokinetics, Inc
  • Are breastfeeding or plan to breastfeed. It is not known if MYQORZO passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment with MYQORZO

Before and during MYQORZO treatment, tell your healthcare provider about all the prescription and over-the-counter medicines, vitamins, and herbal supplements you take. Taking MYQORZO with certain medicines may lead to increased levels of MYQORZO in your blood and increase the risk of heart failure. Do not stop or change the dose of a medicine or start a new medicine without telling your healthcare provider.

Especially tell your healthcare provider if you take fluconazole (if used for more than 3 days), voriconazole, or fluvoxamine.

What are the most common side effects of MYQORZO?

The most common side effect of MYQORZO is high blood pressure (hypertension).

These are not all the possible side effects of MYQORZO. Talk to your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects to Cytokinetics at 1-833-633-2986.

INDICATION AND USAGE

MYQORZO is a prescription medicine used to treat adults with symptomatic obstructive cardiomyopathy (oHCM) to improve functional capacity and symptoms.

It is not known if MYQORZO is safe and effective in children.

Please see full Prescribing Information, including Boxed WARNING, and Medication Guide.